| San Diego did right to help the people of this congregation catch a break. When the demands of the Deity prove too onerous, a person needs to find a way around them, right? PLANNING COMMISSION OF THE CITY OF SAN DIEGO AGENDA May 25, 2006 *CONGREGATION ADAT YESHURUN – PROJECT NO. 48457 City Council District: 1; Plan Area: La Jolla & University City Staff: Robert Tucker Public Right-of-Way Use Permit and a Site Development Permit to install an ERUV line of demarcation for Congregation Adat Yeshurun at the following locations: Torrey Pines Road/La Jolla Villa Drive; Gilman Drive/La Jolla Village Drive; La Jolla Village Drive between Gilman Drive and Villa La Jolla Drive; La Jolla Village Drive between Villa La Jolla Drive and the Interstate 5 South on-ramp; Nobel Drive/Interstate 5 South on-ramp; Gilman Drive near Interstate 5 South on-ramp; across the Interstate 5 South frontage road just south of Gilman Drive; North La Jolla Scenic Drive/La Jolla Parkway; La Jolla Parkway/Torrey Pines Road; and Glenbrook Way and Torrey Pines Road. Mitigated Negative Declaration No. 48467. Report No. PC-06-126. TODAY'S ACTION IS: Process 4. Approve or deny DEPARTMENT RECOMMENDATION: Approve MINUTES OF REGULAR SCHEDULED MEETING OF JUNE 22, 2006 IN CITY COUNCIL CHAMBERS CITY ADMINISTRATION BUILDING ...Continued from May 25, 2006: *CONGREGATION ADAT YESHURUN – PROJECT NO. 48457 Robert Tucker presented Report No. PC-06-126 to the Planning Commission. Speaker slips submitted in favor by Mitchell Berner, Jeff Wohlgelernter, Karl Jacobs, Joyce Abrams, Michael Rosen, Morris Casuto, Irving Samit, Dr. H Mazanslt, Leon Kanner, Jeremy Cohen, Max Slomiarski, John Stump, Arthur Michel, Jonathan Michel, Mitchell Perlitch, David Hastings, Jay Slore, Gerslof Horowitz, Hilda Cotten, Lea Cohen, Janet Klein, Paul Dathow, Joel Rosen, Mark Ellis, Beth Keyman, Gila Saxe, Keigh Saxe, Michael Breslauer, Jeffrey Lazarrow, Jennifer Lazarrow, Audrey Jacobs, Frances Lobman, Chana Gonzalz, Suzanne Marcus, Roy Slavin, Sandra, Saucet, Megan Marcus, Lauren Marcus, Andrew Breskin, Manijen Bredskin, Cloye Jones, David Ellman, Craig Rubinoff, Mohtaram Shodpour, Micheal Cobb, Wendy Burk, Harold Frysh, Floribeth Rappoport, Eva Eiseman, Jamih Eiseman, Barry Kassar, Ara Kassar, Scott Rappoport, Michael Genin, Joseph, Resnitiuff, Susan Thomas, Tina Malka, Dror Yahalom, Elissa Zylberchlag, Dov Borok. Bernice Borok,Diane Shachat, Protima Yahalom, Claire Ellman, Danielle Marcus, Diane Boomer, Charles Jaffe, Orin Green, Sarale Fradkin, Ynev Gobistchen, Hollie Kahn, Randi Grush, Michel Benaroch, Felicia Belcher, Irwin Belcher, Rabbi Zalman Caclebach, Eli Fradkin, Shmuel Fradkin, Morris Derey, Liraz Avioaz, Boaz Zuzan, Motte Fradkin, Robert Mojar, David Levine, Beatriz Frias, Kevin Murray, Abbott Masters III, Marvin Weiss, Robert Sarlin, Karen Ziolo, Cherylyne Rivera, Gordon Williams, Jessica Kipferberg, Julie Datriow, Judith Baitner, Avi Baitner, Jonathan Roth, Stacey Roth, Florence Klinhberg, Irwin Belcher, Judy Lewin, Aaron Lewin, Zachary Dimenstein, Howard Schraub, Jaime Breziner, David Federman, Monica Federman, Necham Carlbech, Leah Fradkin, Musy Fradkin, Tsvi Goldenberg, Aaron Huttman, Simcha Weiser, Yonait Fradkin, Mannie Edelstein, Gail Edelstein, Basil Abromowitz, Michelle Abromowitz, Ronni Rubinoff, Alan Shein, Isaius Walfeuzou, Linda Signer, Diane Shore, Martin Pamensky, Karen Horowitz, jack Forman, Micha Adler, Mary Feifer, David Feifel, Irina Genin, Arthur Klitosky, Jay Shore, Diane Shore, Gershon Horowitz, and Mathew Wetzman. Speaker slip submitted in opposition by Marilyn Olson, Annette Richie-Buis, and Sherri Lightner |
NARSAD
David Feifel, M.D., Ph.D. (Independent Investigator
2004) of University of California, San Diego,
proposes studying in more detail the Brattleboro rat
as a new animal model for schizophrenia. The
Brattleboro rat strain has brain abnormalities due to
a mutation in a single gene that regulates production
of vasopressin. Dr. Feifel’s laboratory recently
discovered that Brattleboro rats have deficits in
prepulse inhibition (PPI) analogous to schizophrenia
patients. PPI refers to the normal reduction of the
startle response to a sudden intense stimulus
(“pulse”) when it is preceded by a much weaker pre-
stimulus (“prepulse”). PPI is thought to reflect the
ability of the brain to filter extraneous environmental
information. Abnormally low PPI is a consistent
finding in unmedicated schizophrenia patients. His
laboratory also found PPI deficits in Brattleboro rats
are reversed by chronic but not acute treatment with
haloperidol, a first generation antipsychotic. In
contrast, clozapine, a second generation
antipsychotic and PD149163, a potential novel
antipsychotic with second-generation features,
significantly enhance PPI in Brattleboro rats after a
single dose. Chronic treatment with these drugs
produced stronger effects. These preliminary
findings suggest the Brattleboro rat may represent a
novel animal model for studying the causes of PPI
deficits exhibited in schizophrenia and for developing
new treatments.
Prepulse inhibition of startle in adults with ADHD
David Feifel, Arpi Minassian, William Perry
Journal: Journal of Psychiatric Research,
ISSN: 0022-3956,
Vol: 43, Issue: 4,
Date: 2009,
Start page: 484, # of pages: 6
David Feifel, M.D., Ph.D. (Independent Investigator
2004) of University of California, San Diego,
proposes studying in more detail the Brattleboro rat
as a new animal model for schizophrenia. The
Brattleboro rat strain has brain abnormalities due to
a mutation in a single gene that regulates production
of vasopressin. Dr. Feifel’s laboratory recently
discovered that Brattleboro rats have deficits in
prepulse inhibition (PPI) analogous to schizophrenia
patients. PPI refers to the normal reduction of the
startle response to a sudden intense stimulus
(“pulse”) when it is preceded by a much weaker pre-
stimulus (“prepulse”). PPI is thought to reflect the
ability of the brain to filter extraneous environmental
information. Abnormally low PPI is a consistent
finding in unmedicated schizophrenia patients. His
laboratory also found PPI deficits in Brattleboro rats
are reversed by chronic but not acute treatment with
haloperidol, a first generation antipsychotic. In
contrast, clozapine, a second generation
antipsychotic and PD149163, a potential novel
antipsychotic with second-generation features,
significantly enhance PPI in Brattleboro rats after a
single dose. Chronic treatment with these drugs
produced stronger effects. These preliminary
findings suggest the Brattleboro rat may represent a
novel animal model for studying the causes of PPI
deficits exhibited in schizophrenia and for developing
new treatments.
Prepulse inhibition of startle in adults with ADHD
David Feifel, Arpi Minassian, William Perry
Journal: Journal of Psychiatric Research,
ISSN: 0022-3956,
Vol: 43, Issue: 4,
Date: 2009,
Start page: 484, # of pages: 6
David Feifel, M.D., Ph.D. |
WCHS ABC
DAVID GARCIA IS A TYPICAL
EIGHT-YEAR-OLD. HE ENJOYS PLAYING IN
THE BACK YARD WITH HIS PARENTS MARTIN
AND ROCIO.
AND HE HAS THE USUAL DOCTOR
CHECK-UPS. BUT HIS VISITS WITH DOCTOR
DAVID FEIFEL ARE DIFFERENT.
DAVID HAS ADHD AND GETS HIS MEDICATION
THROUGH A SKIN PATCH HIDDEN
UNDERNEATH HIS CLOTHES.
David Feifel, M.D., Ph.D.
Neuropsychiatrist
University of California, San Diego
San Diego, CA
"It is essentially the same chemical that is in
Ritalin."
DOCTOR FEIFEL SAYS IT MAY BE THE SAME
CHEMICAL BUT THE PATCH SEEMS TO HAVE
A BIG ADVANTAGE OVER PILLS.
David Feifel, M.D., Ph.D.
"Some of the side effects that we think about
with Ritalin are due to, or at least contributed to,
by the fact that it is a roller-coaster effect."
WITH A PILL, THE LEVEL OF DRUG IN THE
BODY FLUCTUATES CAUSING MOODINESS,
JITTERS OR CHANGES IN APPETITE. THE
PATCH SUPPLIES AN EVEN DOSE OF THE
DRUG AND APPEARS TO REDUCE THE SIDE
EFFECTS.
Martin Garcia
David's Father
"They don't know it's a patch or nothing, and they
just see you like a normal kid."
FOR DAVID, IT SEEMS TO BE WORKING.
David Garcia
Has ADHD
"When I didn't have the patch on, I didn't get that
much homework done."
NOW, IN JUST ONE DAY, HE GETS HIS
HOMEWORK DONE FOR THE ENTIRE WEEK,
AND NO ONE AT SCHOOL HAS TO KNOW HE'S
ON MEDICATION.
Rocio Garcia
David's Mother
"It's very important that it's covered. And it's very
important to me how David feels about himself."
THE MOST COMMON SIDE EFFECTS
ASSOCIATED WITH THE PATCH ARE
TROUBLE SLEEPING AND HEADACHE.
DAVID GARCIA IS A TYPICAL
EIGHT-YEAR-OLD. HE ENJOYS PLAYING IN
THE BACK YARD WITH HIS PARENTS MARTIN
AND ROCIO.
AND HE HAS THE USUAL DOCTOR
CHECK-UPS. BUT HIS VISITS WITH DOCTOR
DAVID FEIFEL ARE DIFFERENT.
DAVID HAS ADHD AND GETS HIS MEDICATION
THROUGH A SKIN PATCH HIDDEN
UNDERNEATH HIS CLOTHES.
David Feifel, M.D., Ph.D.
Neuropsychiatrist
University of California, San Diego
San Diego, CA
"It is essentially the same chemical that is in
Ritalin."
DOCTOR FEIFEL SAYS IT MAY BE THE SAME
CHEMICAL BUT THE PATCH SEEMS TO HAVE
A BIG ADVANTAGE OVER PILLS.
David Feifel, M.D., Ph.D.
"Some of the side effects that we think about
with Ritalin are due to, or at least contributed to,
by the fact that it is a roller-coaster effect."
WITH A PILL, THE LEVEL OF DRUG IN THE
BODY FLUCTUATES CAUSING MOODINESS,
JITTERS OR CHANGES IN APPETITE. THE
PATCH SUPPLIES AN EVEN DOSE OF THE
DRUG AND APPEARS TO REDUCE THE SIDE
EFFECTS.
Martin Garcia
David's Father
"They don't know it's a patch or nothing, and they
just see you like a normal kid."
FOR DAVID, IT SEEMS TO BE WORKING.
David Garcia
Has ADHD
"When I didn't have the patch on, I didn't get that
much homework done."
NOW, IN JUST ONE DAY, HE GETS HIS
HOMEWORK DONE FOR THE ENTIRE WEEK,
AND NO ONE AT SCHOOL HAS TO KNOW HE'S
ON MEDICATION.
Rocio Garcia
David's Mother
"It's very important that it's covered. And it's very
important to me how David feels about himself."
THE MOST COMMON SIDE EFFECTS
ASSOCIATED WITH THE PATCH ARE
TROUBLE SLEEPING AND HEADACHE.
Education Reform Report
